Jurnal Tentang Farmakologi

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Introduction Morphine has long been “gold standard” for the treatment of moderate to severe cancer pain. However, morphine possesses several side effects such as emesis, constipation and drowsiness, which have provoked the use of “opioid rotation” to alternative opioids. Fentanyl, which is a one series of potent opioids synthetic analgesic, has a high affinity for µ-opioid receptor and exhibits 50-100 times more potent analgesic activity than that of morphine. In the clinic, fentanyl is mainly used as .

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